DEPARTMENT OF NEPHROLOGY

The main direction of the Department researches – the study of blood elements’ and vascular endothelial cells’ functional activity in patients with inflammatory renal disease and non-inflammatory progressive nephropathies (diabetic, gouty nephropathies etc.), their role in the immune status changes, in platelet and plasma components of the hemostasis system at various renal pathology types, investigation of the arterial pressure regulation system at vascular endothelial dysfunction and nephrogenous hypertension formation.

The Department of Nephrology was formed in the structure of the Institute of Therapy in 1993.

Most important research results

• Mechanisms of cellular metabolism abnormalities with account of changes in the cells membrane levels of ionized calcium, phospholipids and secondary messengers – phosphoinositols, were studied through experimental models on the animals.

• It was established, that leukocytic-and-endothelial interaction depended on various factors: adhesive molecules expression on leucocytes and endothelial cells, endothelial expression of such products as nitric oxide, endothelin and platelet activation factor.

• It is shown that ischemia during inflammatory and non-inflammatory renal injuries is associated with complement activation and increase of the levels of Villebrand factor and lipid mediators, including leukotrienes, which are neutrophils chemoattractants.

• The studies, carried out in the Department, suggest that nephron dysfunction during glomerulonephritis is the sequence of changes in cells membrane phospholipids fractional composition.

• Positive results of using new metabolic active preparations for prevention of alternative processes at experimental glomerulonephritis on the cellular membrane level enable to apply them clinically.

• Methods of membrane-stabilizing therapy, worked out in the Department, enable to compensate deficit of such polyunsaturated fatty acids.

• The study of effectiveness of steroid pulse therapy and lymphocytapheresis showed the advance of the last treatment in the case of quick-progressing glomerulonephritis. Such results suppose that introduction of methods of both drug and extra corporeal WBC activity correction in the clinical nephrology, along with the immune status, plasma and vascular platelet hemostasis system.

• The study of interconnection of renal destructive processes intensity, degree of internal hemodynamics disturbances and ACE system in patients with inflammatory and non-inflammatory renal disease showed the increase of activity of the system of neurohumoral arterial pressure regulation system in patients with arterial hypertension of renoparenchimatous genesis.

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